衰老大鼠主动脉和血小板中花生四烯酸代谢的变化。

Changes in arachidonate metabolism in aortas and platelets in aging rats.

作者信息

Chang W C, Tai H H

出版信息

Prostaglandins Leukot Med. 1983 Oct;12(2):149-57. doi: 10.1016/0262-1746(83)90078-1.

Abstract

Prostacyclin formation by aortas, thromboxane biosynthesis and 12-lipoxygenase pathway in platelets as a function of age was investigated. Our results indicate an age-related decrease in prostacyclin production by aortas, while no significant change in thromboxane biosynthesis in platelets from mature (12 month old) to senescent (24 month old) rats was observed. Evidence is also presented indicating a decrease in 12-L-hydroperoxy-5,8,10,14-eicosatetraenoic acid (12-HPETE) peroxidase activity in platelets as a function of age.

摘要

研究了主动脉生成前列环素、血小板中血栓素的生物合成以及12-脂氧合酶途径随年龄的变化情况。我们的结果表明，主动脉生成前列环素的能力随年龄增长而下降，而在成熟（12月龄）至衰老（24月龄）大鼠的血小板中，血栓素的生物合成没有显著变化。同时也有证据表明，血小板中12-L-氢过氧-5,8,10,14-二十碳四烯酸（12-HPETE）过氧化物酶活性随年龄增长而降低。