膳食饱和脂肪对大鼠主动脉6-酮-前列腺素F1α合成的特定影响。

Specific effect of dietary saturated fat on rat aortic 6-keto-PGF1 alpha synthesis.

作者信息

Wey H E, Ziller S, Subbiah M T

出版信息

Prostaglandins Leukot Med. 1983 Oct;12(2):169-74. doi: 10.1016/0262-1746(83)90080-x.

Abstract

The effect of dietary lard and corn oil-supplementation on rat aortic 6-keto-PGF1 alpha synthesis from both exogenous and endogenous arachidonic acid was investigated. Only lard-supplementation resulted in any change when compared to rats fed normal chow. Lard-supplementation resulted in both a significant increase in the conversion of exogenous arachidonic acid to 6-keto-PGF1 alpha and a significant decrease in the ratio of linoleate to arachidonate in aortic phospholipids. Basal aortic synthesis of 6-keto-PGF1 alpha from endogenous arachidonic acid was not different for any group. We conclude that at least for the aortic conversion of exogenous arachidonic acid to 6-keto-PGF1 alpha the level of inhibitor linoleic acid in tissue phospholipids may be important.

摘要

研究了膳食中补充猪油和玉米油对大鼠主动脉从外源性和内源性花生四烯酸合成6-酮-前列腺素F1α的影响。与喂食普通饲料的大鼠相比，只有补充猪油导致了变化。补充猪油导致外源性花生四烯酸向6-酮-前列腺素F1α的转化率显著增加，同时主动脉磷脂中亚油酸与花生四烯酸的比例显著降低。任何一组内源性花生四烯酸的基础主动脉6-酮-前列腺素F1α合成均无差异。我们得出结论，至少对于外源性花生四烯酸向6-酮-前列腺素F1α的主动脉转化，组织磷脂中抑制剂亚油酸的水平可能很重要。