Nour-Eldin F
Transfusion. 1983 Nov-Dec;23(6):533-4. doi: 10.1046/j.1537-2995.1983.23684074281.x.
When Bridge anticoagulant neutralizing agent, prepared by column fractionation, was infused with factor VIII concentrate into a hemophilic dog, the apparent level of circulating factor VIII was markedly increased. Material isolated from 30 ml donor plasma raised the level of factor VIII nearly three-fold, during the first post-transfusion hour. This was achieved without shortening the period during which a hemostatically-effective level of factor VIII was maintained. The same dose also reduced the amount of factor VIII required for prompt and successful hemostasis after standardized template gingival biopsy.
当通过柱分级分离制备的桥梁抗凝中和剂与因子VIII浓缩物一起注入一只血友病犬体内时，循环中因子VIII的表观水平显著升高。从30毫升供体血浆中分离出的物质在输血后的第一个小时内使因子VIII水平提高了近三倍。在保持因子VIII止血有效水平的时间段不缩短的情况下实现了这一点。相同剂量还减少了标准化模板牙龈活检后迅速成功止血所需的因子VIII量。
