Kingdon H S, Hassell T M
Blood. 1981 Nov;58(5):868-72.
Therapeutic effectiveness of factor VIII inhibitor bypassing materials has been evaluated in dogs with hemophilia A. A standardized template gingival biopsy was performed using local anesthesia. Hemophilic dogs bled extensively from the biopsy site, whereas in normal dogs the wound was sealed within 5 + /- 2 min. If untreated, the hemophilic dogs frequently bled for several days. Factor VIII infusion stopped the bleeding promptly. Some experimental preparations of factor VIII inhibitor bypassing materials were shown to be therapeutically effective, whereas others were not. Intravascular thrombi could not be demonstrated histologically. The model should prove useful for evaluating factor VIII inhibitor bypassing materials and also for evaluating their mechanism of action.
已在患有A型血友病的犬中评估了凝血因子VIII抑制剂旁路制剂的治疗效果。使用局部麻醉进行标准化的牙龈活检模板操作。血友病犬从活检部位大量出血，而正常犬的伤口在5±2分钟内就会愈合。如果不进行治疗，血友病犬经常会出血数天。输注凝血因子VIII可迅速止血。一些凝血因子VIII抑制剂旁路制剂的实验制剂显示出治疗效果，而其他制剂则没有。组织学检查未发现血管内血栓形成。该模型应证明对评估凝血因子VIII抑制剂旁路制剂及其作用机制有用。
