Lithell H, Weiner E, Vessby B, Johansson E D
Ups J Med Sci. 1983;88(2):103-8. doi: 10.3109/03009738309178443.
The lipoprotein and carbohydrate metabolism was studied during contraceptive treatment with levonorgestrel, released at a low rate (70 micrograms/day) from subcutaneous capsules, in five women who were treated for 180-403 days. The serum cholesterol concentration decreased slightly but significantly during treatment. This was attributable to a tendency to a reduction of cholesterol in high-density lipoproteins. The treatment did not affect the lipoprotein lipase activity in adipose tissue. The elimination rates of intravenously injected fat and glucose were unchanged, as were the serum insulin concentrations. Thus, in this pilot study the concentration and composition of the serum lipoproteins altered to only a minor extent during treatment with levonorgestrel in a dose of 70 micrograms/day.
对5名女性进行了研究，她们皮下植入了以低速率（70微克/天）释放左炔诺孕酮的胶囊，避孕治疗持续180 - 403天，在此期间对她们的脂蛋白和碳水化合物代谢进行了研究。治疗期间血清胆固醇浓度略有下降，但具有显著性。这归因于高密度脂蛋白中胆固醇有降低的趋势。该治疗不影响脂肪组织中的脂蛋白脂肪酶活性。静脉注射脂肪和葡萄糖的清除率未变，血清胰岛素浓度也未变。因此，在这项初步研究中，每天70微克剂量的左炔诺孕酮治疗期间，血清脂蛋白的浓度和组成仅发生了轻微变化。
