Kelly L E
Cell Mol Neurobiol. 1983 Jun;3(2):143-9. doi: 10.1007/BF00735278.
Mutations at the stoned locus of Drosophila melanogaster produce a reversible temperature-sensitive debilitation. At permissive temperatures they also exhibit an unusual jump response to a light-off stimulus. An increase in the amplitude of the off-transient of the electroretinogram (ERG) is associated with the abnormal jump. Both the jump response and the increased amplitude of the off-transient are shown to be dependent on the duration of the light pulse prior to the light-off stimulus. In stoned flies which are light adapted, the jump response, as measured by recording from the indirect flight muscles, is seen to habituate with increasing light-off frequency. This habituation corresponds to the decrease in the amplitude of the off-transient that also occurs with high-frequency stimulation. Another visual mutant tan, removes the off and on-transients of the ERG. The combining of the stoned mutation with tan in the tan, stoned double mutant results in the loss of the jump behavior as well as the partial restoration of the off-transient to an otherwise tan-like ERG. The relationship between the increase in the amplitude of the off-transient in stoned flies and the eliciting of the jump response is discussed.
黑腹果蝇“stoned”基因座的突变会产生一种可逆的温度敏感型衰弱。在允许温度下，它们对熄灯刺激还表现出异常的跳跃反应。视网膜电图（ERG）熄灭瞬变的幅度增加与这种异常跳跃有关。跳跃反应和熄灭瞬变幅度的增加都被证明取决于熄灯刺激之前光脉冲的持续时间。在适应光照的“stoned”果蝇中，通过记录间接飞行肌发现，跳跃反应会随着熄灯频率的增加而习惯化。这种习惯化与高频刺激时也会出现的熄灭瞬变幅度减小相对应。另一个视觉突变体“tan”，会消除ERG的熄灭和开启瞬变。在“tan，stoned”双突变体中，将“stoned”突变与“tan”突变相结合，会导致跳跃行为丧失，以及熄灭瞬变部分恢复到类似“tan”的ERG状态。文中讨论了“stoned”果蝇中熄灭瞬变幅度增加与跳跃反应引发之间的关系。
