Scott M P, Weiner A J, Hazelrigg T I, Polisky B A, Pirrotta V, Scalenghe F, Kaufman T C
Cell. 1983 Dec;35(3 Pt 2):763-76. doi: 10.1016/0092-8674(83)90109-5.
The Antennapedia complex (ANT-C) of Drosophila is a cluster of genes involved in the regulation of morphogenesis, including at least three homoeotic loci (Antp, Scr, and pb), in which mutations cause switches of cell fates from one developmental pathway to another. We have isolated DNA clones containing most of the ANT-C, a region of about 300 kb. Antp mutations are distributed across more than 100 kb of the ANT-C. Dominant Antp mutations are associated with certain chromosome rearrangements and insertions that interrupt the 100 kb region; other chromosome breaks within the region cause recessive lethality and have no dominant effects. Two prominent transcripts (3.5 and 5.0 kb) are derived from exons within and at the two ends of the 100 kb region.
果蝇的触角足复合体（ANT-C）是一组参与形态发生调控的基因簇，其中至少包括三个同源异型基因座（Antp、Scr和pb），这些基因座中的突变会导致细胞命运从一种发育途径转换到另一种发育途径。我们已经分离出包含大部分ANT-C的DNA克隆，该区域约为300 kb。Antp突变分布在ANT-C的100多kb区域内。显性Antp突变与某些染色体重排和插入相关，这些重排和插入会中断100 kb区域；该区域内的其他染色体断裂会导致隐性致死，且没有显性效应。两种主要的转录本（3.5 kb和5.0 kb）来源于100 kb区域内部和两端的外显子。
