Lawrence G M, Brewer D B
Clin Sci (Lond). 1984 Jan;66(1):47-54. doi: 10.1042/cs0660047.
Urinary clearances of bovine albumin derivatives rose with their increasing negative charge. A mathematical model has been developed to assess the relative contributions of glomerular ultrafiltration and tubular reabsorption to overall urinary protein clearance. This model indicates that the increased urinary clearance seen with negatively charged bovine albumin derivatives was due to a large reduction in the amount of protein absorbed by the proximal tubular epithelium, which swamped the effects of a small decrease in glomerular ultrafiltration. Derivatives of bovine albumin with increasing negative charge were also cleared with correspondingly greater rapidity from the blood stream.
牛血清白蛋白衍生物的尿清除率随着其负电荷的增加而升高。已建立一个数学模型来评估肾小球超滤和肾小管重吸收对整体尿蛋白清除率的相对贡献。该模型表明，带负电荷的牛血清白蛋白衍生物尿清除率增加是由于近端肾小管上皮细胞吸收的蛋白量大幅减少，这掩盖了肾小球超滤少量减少的影响。带负电荷增加的牛血清白蛋白衍生物也从血流中以相应更快的速度被清除。
