Vierhapper H, Bratusch-Marrain P, Waldhäusl W
Exp Clin Endocrinol. 1983 Nov;82(3):372-5. doi: 10.1055/s-0029-1210301.
The intravenous administration of prostaglandin E2 (PGE2) has been proposed as a diagnostic tool in the differentiation of hypothalamic and pituitary forms of growth hormone deficiency. We have therefore studied the effect of PGE2 (200 micrograms i.v.) on serum concentrations of GH, LH, FSH, PRL, TSH, and cortisol in six healthy, male subjects. Side-effects, reported as highly unpleasant, occurred within two minutes after i.v. PGE2 in each individual. The individual response in serum concentrations of GH and LH following PGE2 was variable. Thus, a stimulatory effect was seen in some, but not in all individuals. Concentrations of FSH, PRL, and TSH did not change after PGE2-challenge, but a transient rise in serum cortisol was observed (p less than 0.01). The release of GH and LH upon i.v. PGE2 may be part of a systemic reaction or be due to a direct action of PGE2 on the anterior pituitary. The inhomogeneity of the obtained results and the unpleasant side-effects of i.v. PGE2 disqualify its use for the evaluation of pituitary GH-releasing capacity.
静脉注射前列腺素E2（PGE2）已被提议作为一种诊断工具，用于区分下丘脑性和垂体性生长激素缺乏症。因此，我们研究了PGE2（静脉注射200微克）对6名健康男性受试者血清中生长激素（GH）、促黄体生成素（LH）、促卵泡生成素（FSH）、催乳素（PRL）、促甲状腺激素（TSH）和皮质醇浓度的影响。静脉注射PGE2后两分钟内，每个人都出现了被报告为非常不适的副作用。PGE2注射后，血清中GH和LH的个体反应各不相同。因此，在一些个体中观察到了刺激作用，但并非所有个体都如此。PGE2刺激后，FSH、PRL和TSH的浓度没有变化，但观察到血清皮质醇出现短暂升高（p<0.01）。静脉注射PGE2后GH和LH的释放可能是全身反应的一部分，或者是由于PGE2对垂体前叶的直接作用。所获得结果的不均匀性以及静脉注射PGE2带来的不适副作用，使其不适合用于评估垂体GH释放能力。
