Döcke F, Rohde W, Dörner G
Exp Clin Endocrinol. 1983 Nov;82(3):384-7. doi: 10.1055/s-0029-1210304.
Immature female rats were bilaterally lesioned or sham-lesioned in the anterior part of the medial amygdaloid nucleus (AMN) at 21 days of age, and the serum FSH and LH concentrations were estimated in groups of rats autopsied at daily intervals from day 21 through day 28. Whereas the LH concentration did not differ between lesioned females and the controls, a highly significant elevation of the circulating FSH level was recorded in the lesioned rats from day 22 till day 24. A further experiment demonstrated that similar lesions did not change the FSH and LH-inhibiting effect of estrogen in rats that were ovariectomized on day 22, daily injected with 0.05 microgram estradiol benzoate per 100 g b.w. on days 22 and 23, and sacrificed 24 hr after the last injection. The results suggest that the AMN exerts a restraining influence on the hypophyseal FSH secretion around 21 days of age, and that this inhibitory activity does not depend upon sensitization to the negative feed-back of estrogen.
未成熟雌性大鼠在21日龄时双侧损毁或假损毁杏仁核内侧核（AMN）前部，从21日至28日每天对大鼠进行尸检，估计血清促卵泡激素（FSH）和促黄体生成素（LH）浓度。虽然损毁雌性大鼠与对照组的LH浓度没有差异，但从22日至24日，损毁大鼠的循环FSH水平显著升高。进一步的实验表明，在22日进行卵巢切除、22日和23日每天每100 g体重注射0.05微克苯甲酸雌二醇、最后一次注射24小时后处死的大鼠中，类似的损毁不会改变雌激素对FSH和LH的抑制作用。结果表明，AMN在21日龄左右对垂体FSH分泌发挥抑制作用，且这种抑制活性不依赖于对雌激素负反馈的敏感性。
