Döcke F, Lung D N, Rohde W, Dörner G
Endokrinologie. 1982 Jun;79(2):311-4.
Diestrous female rats were bilaterally lesioned in the perisuprachiasmatic region (peri-SCN region) or in the medial preoptic area (MPOA) and ovariectomized immediately after lesioning. Blood was collected at one hour before and at 4.24 and 48 h after surgery. Radioimmunological determination of the serum gonadotropin concentrations revealed that lesioning of the peri-SCN region enhanced significantly the castration-induced increase of FSH and LH secretion at 4 and 24 h, whereas MPOA lesions did not influence the serum hormone levels as compared to the sham-lesioned controls. The findings suggest that the peri-SCN region, but not the MPOA may be involved in the control of the increase of gonadotropin secretion following ovariectomy in rats.
处于间情期的雌性大鼠在视交叉上核周围区域（视交叉上核周围区域）或内侧视前区（MPOA）进行双侧损伤，并在损伤后立即进行卵巢切除。在手术前1小时以及手术后4、24和48小时采集血液。通过放射免疫法测定血清促性腺激素浓度，结果显示，视交叉上核周围区域的损伤在4小时和24小时时显著增强了去势诱导的促卵泡激素（FSH）和促黄体生成素（LH）分泌的增加，而与假手术对照组相比，MPOA损伤并未影响血清激素水平。这些发现表明，视交叉上核周围区域而非MPOA可能参与了大鼠卵巢切除后促性腺激素分泌增加的调控。
