Bundgaard A, Buch D, Schmidt A, Bach-Mortensen N
Eur J Respir Dis Suppl. 1983;130:36-41.
The effect of pretreatment with inhalation powder containing fenoterol, sodium cromoglycate, fenoterol plus sodium cromoglycate and placebo, in the prevention of exercise-induced asthma was compared in a randomized, double-blind, cross-over investigation including 17 asthmatic children with exercise-induced asthma. Six minutes of treadmill running was carried out in a climate chamber 30 minutes after pretreatment on the four test days. The post-exercise fall in PEF after pretreatment with fenoterol was 7%, with sodium cromoglycate 20%, with fenoterol plus sodium cromoglycate 6% and after placebo 27%. Both sodium cromoglycate and fenoterol provided protection against exercise-induced asthma (p less than 0.05 and p less than 0.001). Fenoterol gave significantly better protection than sodium cromoglycate (p less than 0.001), and it is concluded that the treatment of choice for the prevention of exercise-induced asthma is the inhalation of a beta 2-agonist.
在一项随机、双盲、交叉研究中，对17名运动诱发性哮喘儿童使用含有非诺特罗、色甘酸钠、非诺特罗加色甘酸钠及安慰剂的吸入粉剂进行预处理，比较其预防运动诱发性哮喘的效果。在四个测试日进行预处理30分钟后，于气候舱内进行6分钟的跑步机跑步。用非诺特罗预处理后运动后呼气峰流速（PEF）下降7%，用色甘酸钠下降20%，用非诺特罗加色甘酸钠下降6%，用安慰剂下降27%。色甘酸钠和非诺特罗均可预防运动诱发性哮喘（p<0.05和p<0.001）。非诺特罗的预防效果显著优于色甘酸钠（p<0.001），得出结论：预防运动诱发性哮喘的首选治疗方法是吸入β2激动剂。
