Faccio Dolfini S, Bonifazio Razzini A
Experientia. 1983 Dec 15;39(12):1402-4. doi: 10.1007/BF01990127.
A DNA-binding AT-specific antibiotic, distamycin A, was used as inhibitor of the condensation process of the heterochromatic regions in Drosophila melanogaster embryonic cells. By this treatment the structural organization of heterochromatin at interphase is preserved until metaphase. The different patterns observed are interpreted as chronological steps in the condensation process.
一种与DNA结合的AT特异性抗生素——放线菌素A，被用作果蝇胚胎细胞异染色质区域浓缩过程的抑制剂。通过这种处理，间期异染色质的结构组织得以保留至中期。观察到的不同模式被解释为浓缩过程中的时间顺序步骤。
