Rogers A W, Wischik C M
J Anat. 1983 Oct;137 (Pt 3)(Pt 3):541-53.
The organisation and activity of cells in the uterine stroma of ovariectomised rats have been studied over the 24 hours following an injection of progesterone. Autoradiographically, the rate of incorporation of [3H]lysine falls 1 hour after progesterone, rising progressively at 3 and 7 hours to levels higher than in control animals. A gradient of grain density is evident at 1, 3 and 7 hours, higher in regions adjacent to luminal epithelium than near the muscularis. No such gradient appears relative to glandular epithelium. Morphometric studies show that the array of stromal cells 24 hours after progesterone is similar to that in control rats, except that cells near the luminal epithelium are larger in the former group. At intermediate times, changes in cell size and spacing occur throughout the stroma in patterns that vary with distance from luminal epithelium. The organisation and activity of cells in the uterine stroma change in response to progesterone in a manner conditioned by their position in the uterus, in particular by their distance from luminal epithelium.
在给去卵巢大鼠注射孕酮后的24小时内，对其子宫基质中细胞的组织和活性进行了研究。通过放射自显影术发现，注射孕酮1小时后，[3H]赖氨酸的掺入率下降，在3小时和7小时逐渐上升至高于对照动物的水平。在1小时、3小时和7小时时，可见颗粒密度梯度，靠近腔上皮的区域比靠近肌层的区域更高。相对于腺上皮则未出现这种梯度。形态计量学研究表明，注射孕酮24小时后基质细胞的排列与对照大鼠相似，只是前一组中靠近腔上皮的细胞更大。在中间时间段，整个基质中细胞大小和间距的变化模式随距腔上皮的距离而变化。子宫基质中细胞的组织和活性会根据孕酮的作用而发生变化，其变化方式受细胞在子宫中的位置影响，特别是受其与腔上皮距离的影响。
