Oki K, Kinoshita Y, Nomura Y, Segawa T
J Pharmacobiodyn. 1983 Sep;6(9):607-12. doi: 10.1248/bpb1978.6.607.
An intraperitoneal administration of thyrotropin-releasing hormone (TRH, 2 or 20 mg/kg) produced behavioral excitement and consequently an increase in ANIMEX counts 15 min after the injection in a dose-dependent manner in 70-day-old rats. On the other hand, TRH (2 or 20 mg/kg)-induced behavioral excitement appeared more slowly (90-150 min) and more persistently in 7-day-old animals than in 70-day-old animals. TRH (2 or 20 mg/kg) significantly reduced specific [3H]spiperone binding to striatal membranes in 7- and 70-day-old rats compared to control, when the binding was examined in the membranes obtained from animals sacrificed 15 min and 150 min following TRH injection. In vitro addition of TRH up to 0.1 mM did not affect [3H]spiperone binding on days 7 and 70. From these results, it is suggested that striatal dopamine receptors could be involved in TRH-induced behavioral excitement in developing rats.
对70日龄大鼠腹腔注射促甲状腺激素释放激素（TRH，2或20毫克/千克）会产生行为兴奋，因此注射后15分钟时动物活动计数呈剂量依赖性增加。另一方面，TRH（2或20毫克/千克）诱导的行为兴奋在7日龄动物中出现得更慢（90 - 150分钟）且持续时间更长，相比70日龄动物。当在TRH注射后15分钟和150分钟处死动物获取的纹状体膜中检测结合情况时，与对照组相比，TRH（2或20毫克/千克）显著降低了7日龄和70日龄大鼠纹状体膜中特异性[3H]螺哌隆结合。在第7天和第70天，体外添加高达0.1毫摩尔的TRH对[3H]螺哌隆结合无影响。从这些结果推测，纹状体多巴胺受体可能参与了发育中大鼠TRH诱导的行为兴奋。
