Oki K, Nomura Y, Segawa T
J Pharmacobiodyn. 1982 Sep;5(9):716-9. doi: 10.1248/bpb1978.5.716.
A subcutaneous (s.c.) injection of thyrotropin-releasing hormone (TRH) 20 mg/kg, produced body shake and struggle, consequently induced an increase of count in ANIMEX activity meter in 7-day-old rats pretreated with 6-hydroxydopa (6-OHDOPA), 75 mg/kg, on days 0, 2 and 4. TRH-induced behavioral excitement was markedly attenuated in the infant animals which were injected desmethylimipramine, 5 mg/kg, 30 min before 6-OHDOPA on days 0, 2 and 4. It is suggested that central catecholaminergic, in particular, noradrenergic system is involved in TRH-induced body shake and struggle in 6-OHDOPA-treated, infant rats.
皮下注射促甲状腺激素释放激素（TRH）20毫克/千克，会引起身体颤抖和挣扎，从而导致在第0、2和4天用75毫克/千克的6-羟基多巴胺（6-OHDOPA）预处理的7日龄大鼠的ANIMEX活动计计数增加。在第0、2和4天，在注射6-OHDOPA前30分钟注射5毫克/千克去甲丙咪嗪的幼龄动物中，TRH诱导的行为兴奋明显减弱。这表明中枢儿茶酚胺能系统，特别是去甲肾上腺素能系统，参与了6-OHDOPA处理的幼龄大鼠中TRH诱导的身体颤抖和挣扎。
