阉割雄性小鼠中睾酮5α-还原酶活性的抑制及附属生殖组织的生长
Inhibition of testosterone 5alpha-reductase activity and growth of accessory sex tissues in castrated male mice.
作者信息
Luttge W G, Jasper T W, Sheets C S, Gray H E
出版信息
J Reprod Fertil. 1978 May;53(1):45-50. doi: 10.1530/jrf.0.0530045.
PMID:641896
Abstract
The steroid 4-androsten-3-one-17beta-carboxylic acid (17betaC) reduced the growth-promoting actions of testosterone, but not those of DHT in accessory sex tissues of castrated mice. The 5alpha-reduction of testosterone to DHT in these tissues was also reduced by 17betaC treatment, suggesting that DHT formation is a required step in the mechanism of action of testosterone.
摘要
甾体4-雄烯-3-酮-17β-羧酸（17βC）可降低睾酮对去势小鼠附属生殖器官的促生长作用，但对双氢睾酮（DHT）无此作用。17βC处理还可降低这些组织中睾酮向DHT的5α-还原作用，提示DHT的形成是睾酮作用机制中的一个必要步骤。
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