Bartness T J, Rowland N
Physiol Behav. 1983 Oct;31(4):546-54. doi: 10.1016/0031-9384(83)90080-x.
Rats which were experimentally diabetic (streptozotocin, 45 or 70 mg/kg, or pancreatectomized) and their nondiabetic controls were allowed to select ad lib from three pure macronutrient sources of carbohydrate (CHO), protein, and fat. After full adaptation, the intakes were examined 2, 4, 6, and 24 hr following an intragastric load given at the end of the daytime. Noncaloric (control) or isocaloric loads of CHO or protein or fat were studied. Fat loads suppressed subsequent fat intake reasonably selectively; CHO and protein loads suppressed the intake of the corresponding macronutrient, but less selectively. There were no major qualitative differences between diabetic and nondiabetic rats.
将实验性糖尿病大鼠（用链脲佐菌素，剂量为45或70毫克/千克，或进行胰腺切除）及其非糖尿病对照大鼠置于三种纯常量营养素来源（碳水化合物、蛋白质和脂肪）中，任其自由选择进食。充分适应后，在白天结束时给予胃内负荷，分别于2、4、6和24小时后检查摄入量。研究了非热量（对照）或等热量的碳水化合物、蛋白质或脂肪负荷。脂肪负荷能合理且有选择性地抑制随后的脂肪摄入；碳水化合物和蛋白质负荷能抑制相应常量营养素的摄入，但选择性较差。糖尿病大鼠和非糖尿病大鼠之间没有重大的质性差异。
