Kanarek R B, Ho L
Physiol Behav. 1984 Apr;32(4):639-45. doi: 10.1016/0031-9384(84)90319-6.
The effects of experimental diabetes on energy intake, patterns of nutrient selection, water intake, body weight and body composition were examined in male Sprague-Dawley rats given ground Purina Chow or a dietary self-selection regime. Following adaptation to dietary conditions, a portion of the animals in each diet group were made diabetic by the administration of 45 mg/kg streptozotocin (STZ). The remaining animals in each group served as vehicle-injected controls. STZ reliably produced diabetes in rats on both dietary regimes. Immediately after the induction of diabetes, rats on the self-selection regime increased carbohydrate and protein intakes and decreased fat intake. Approximately three weeks after STZ administration, diabetic rats reduced carbohydrate intake and increased fat intake. Diabetic animals in both diet groups were hyperphagic and polydipsic relative to non-diabetic controls. During the first three weeks following STZ injections, energy and water intakes of diabetic animals in the two dietary conditions were similar. However, after this initial period, energy and water intakes of diabetic rats given the self-selection regime were significantly lower than those of diabetic animals given Purina Chow.
在给予普瑞纳（Purina）磨碎饲料或饮食自选方案的雄性斯普拉格-道利（Sprague-Dawley）大鼠中，研究了实验性糖尿病对能量摄入、营养选择模式、水摄入、体重和身体成分的影响。在适应饮食条件后，每个饮食组中的一部分动物通过注射45 mg/kg链脲佐菌素（STZ）诱导糖尿病。每组中其余动物作为注射溶媒的对照。在两种饮食方案下，STZ均能可靠地使大鼠患糖尿病。在诱导糖尿病后，采用自选饮食方案的大鼠立即增加了碳水化合物和蛋白质的摄入量，减少了脂肪摄入量。在给予STZ约三周后，糖尿病大鼠减少了碳水化合物摄入量，增加了脂肪摄入量。相对于非糖尿病对照组，两个饮食组中的糖尿病动物均食欲亢进且饮水过多。在注射STZ后的前三周内，两种饮食条件下糖尿病动物的能量和水摄入量相似。然而，在此初始阶段之后，采用自选饮食方案的糖尿病大鼠的能量和水摄入量显著低于给予普瑞纳饲料的糖尿病动物。
