Ando K, Johanson C E, Levy D L, Yasillo N J, Holzman P S, Schuster C R
Psychopharmacology (Berl). 1983;81(4):295-300. doi: 10.1007/BF00427566.
Rhesus monkeys were trained to track a moving disk using a procedure in which responses on a lever were reinforced with water delivery only when the disk, oscillating in a horizontal plane on a screen at a frequency of 0.4 Hz in a visual angle of 20 degrees, dimmed for a brief period. Pursuit eye movements were recorded by electrooculography (EOG). IM phencyclidine, secobarbital, and diazepam injections decreased the number of reinforced lever presses in a dose-related manner. Both secobarbital and diazepam produced episodic jerky-pursuit eye movements, while phencyclidine had no consistent effects on eye movements. Lever pressing was disrupted at doses which had little effect on the quality of smooth-pursuit eye movements in some monkeys. This separation was particularly pronounced with diazepam. The similarities of the drug effects on smooth-pursuit eye movements between the present study and human studies indicate that the present method using rhesus monkeys may be useful for predicting drug effects on eye tracking and oculomotor function in humans.
恒河猴接受训练，通过一种程序追踪移动圆盘，在该程序中，只有当圆盘在屏幕上以20度视角、0.4赫兹频率在水平面上振荡并短暂变暗时，杠杆上的反应才会通过给予水来强化。通过眼电图（EOG）记录追踪性眼球运动。注射IM苯环己哌啶、速可巴比妥和地西泮会以剂量相关的方式减少强化杠杆按压的次数。速可巴比妥和地西泮都会产生间歇性的急促追踪性眼球运动，而苯环己哌啶对眼球运动没有一致的影响。在某些猴子中，对平稳追踪性眼球运动质量影响很小的剂量就会干扰杠杆按压。这种分离在地西泮的情况下尤为明显。本研究与人体研究中药物对平稳追踪性眼球运动的影响相似，表明目前使用恒河猴的方法可能有助于预测药物对人类眼球追踪和动眼功能的影响。
