Lipton R B, Levin S, Holzman P S
Psychiatry Res. 1980 Oct;3(2):193-203. doi: 10.1016/0165-1781(80)90036-0.
Sixteen schizophrenic patients, 16 manic-depressive patients, and 14 nonpatient control subjects were tested for horizontal and vertical smooth pursuit eye movements (SPEM) and the oculocephalic reflex. All patients with impaired horizontal pursuit also displayed disrupted vertical pursuit, suggesting that a common mechanism underlies these abnormalities. The oculocephalic reflex was intact in 96% of the subjects whether or not pursuit was disrupted, suggesting that the locus of the eye movement disorder in psychosis may be cortical. For horizontal pursuit, there were significant differences between schizophrenics and nonpatient controls, and between manic depressives and nonpatient controls, but not between schizophrenics and manic depressives, suggesting that the SPEM disruption occurs with significant prevalence in major functional psychoses and not only in schizophrenia.
对16名精神分裂症患者、16名躁郁症患者和14名非患者对照受试者进行了水平和垂直平滑追踪眼球运动（SPEM）以及眼头反射测试。所有水平追踪受损的患者也表现出垂直追踪紊乱，这表明这些异常情况存在共同的机制。无论追踪是否受到干扰，96%的受试者眼头反射均正常，这表明精神病患者眼球运动障碍的部位可能在皮层。对于水平追踪，精神分裂症患者与非患者对照之间、躁郁症患者与非患者对照之间存在显著差异，但精神分裂症患者与躁郁症患者之间无显著差异，这表明SPEM紊乱在主要功能性精神病中普遍存在，而不仅限于精神分裂症。
