Nelimarkka O, Niinikoski J
Surg Gynecol Obstet. 1984 Jan;158(1):27-32.
Renal cortical and medullary tissue pO2 and pCO2 were measured by means of implanted Silastic tonometers during arterial occlusion and graded hemorrhage in dogs. The results of studies of tissue pO2 decay curves after interruption of renal circulation suggest that a mean critical pO2 level for oxygen consumption is 15 millimeters of mercury for the cortex and 13 millimeters of mercury for the medulla. Aerobic oxidative metabolism ceased at a pO2 value of 6 millimeters of mercury in both tissue layers. At this phase, carbon dioxide was produced anaerobically in both tissue layers. In graded hemorrhage, the critical pO2 level for oxygen consumption and the minimum pO2 value for aerobic oxidative metabolism were reached earlier in the cortex than in the medulla, which may contribute to the frequent occurrence of ischemic damage and necrosis in the renal cortex after severe hemorrhagic shock.
在犬的动脉闭塞和分级出血过程中，通过植入的硅橡胶张力计测量肾皮质和髓质组织的氧分压（pO₂）和二氧化碳分压（pCO₂）。肾循环中断后组织pO₂衰减曲线的研究结果表明，皮质耗氧的平均临界pO₂水平为15毫米汞柱，髓质为13毫米汞柱。在两个组织层中，当pO₂值为6毫米汞柱时，有氧氧化代谢停止。在此阶段，两个组织层均通过无氧方式产生二氧化碳。在分级出血过程中，皮质比髓质更早达到耗氧的临界pO₂水平以及有氧氧化代谢的最低pO₂值，这可能是严重失血性休克后肾皮质频繁发生缺血性损伤和坏死的原因。
