氯化石蜡：多氯-[1-¹⁴C]-十六烷在鲤鱼（Cyprinus carpio）和银鲫（Alburnus alburnus）体内的分布情况。

Chlorinated paraffins: disposition of a polychloro-[1-14C]-hexadecane in carp (Cyprinus carpio) and bleak (Alburnus alburnus).

作者信息

Darnerud P O, Bengtsson B E, Bergman A, Brandt I

出版信息

Toxicol Lett. 1983 Dec;19(3):345-51. doi: 10.1016/0378-4274(83)90141-8.

PMID:6419402

Abstract

The disposition of polychloro-[1-14C]hexadecane (PCHD, 34% chlorine w/w) was studied in carp (Cyprinus carpio) and bleak (Alburnus alburnus). After intra-arterial (i.a.) injection in carp about 6% of dose was excreted as 14CO2 in 96 h. The autoradiographic distribution pattern after administration of PCHD to carp (i.a.) and bleak (up to 14 days of exposure in PCHD-contaminated water) was characterized by a strong labelling in the bile/intestinal contents. High radioactivity also appeared in the kidney, liver, gills and, particularly in bleak, in the nasal cavity, lens and skin.

摘要

研究了多氯代-[1-¹⁴C]十六烷（PCHD，氯含量34%，重量比）在鲤鱼（Cyprinus carpio）和赤睛鱼（Alburnus alburnus）体内的分布情况。在鲤鱼体内进行动脉内注射后，约6%的剂量在96小时内以¹⁴CO₂的形式排出。给鲤鱼进行动脉内注射PCHD以及让赤睛鱼在受PCHD污染的水中暴露长达14天后，放射自显影的分布模式表现为胆汁/肠道内容物中有强烈的标记。肾脏、肝脏、鳃中也出现高放射性，特别是在赤睛鱼中，鼻腔、晶状体和皮肤中也有高放射性。