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肯尼亚人群中针对出血热病毒的抗体。

Antibodies against haemorrhagic fever viruses in Kenya populations.

作者信息

Johnson B K, Ocheng D, Gichogo A, Okiro M, Libondo D, Tukei P M, Ho M, Mugambi M, Timms G L, French M

出版信息

Trans R Soc Trop Med Hyg. 1983;77(5):731-3. doi: 10.1016/0035-9203(83)90216-x.

Abstract

Human sera from Lodwar (77 sera), Nzoia (841 sera), Masinga (251 sera), Laisamis (174 sera) and the Malindi/Kilifi area (556 sera) in Kenya were tested by indirect immunofluorescence for antibodies against Marburg, Ebola (Zaire and Sudan strains), Congo haemorrhagic fever, Rift Valley fever and Lassa viruses. Antibodies against Ebola virus, particularly the Zaire strain, were detected in all regions and were, over-all, more abundant than antibodies against the other antigens. Ebola and Marburg antibody prevalence rates were highest in the samples from Lodwar and Laisamis, both semi-desert areas. Antibodies against Rift Valley fever virus were also highest in the Lodwar sample followed by Malindi/Kilifi and Laisamis. Congo haemorrhagic fever virus antibodies were rare and no antibodies against Lassa virus were detected in the 1899 sera tested.

摘要

采用间接免疫荧光法对肯尼亚洛德瓦尔(77份血清)、恩佐亚(841份血清)、马辛加(251份血清)、莱萨米斯(174份血清)以及马林迪/基利菲地区(556份血清)的人类血清进行检测,以检测其针对马尔堡病毒、埃博拉病毒(扎伊尔和苏丹毒株)、刚果出血热病毒、裂谷热病毒和拉沙病毒的抗体。在所有地区均检测到了针对埃博拉病毒的抗体,尤其是扎伊尔毒株,总体而言,其抗体数量比针对其他抗原的抗体更多。在洛德瓦尔和莱萨米斯(均为半沙漠地区)的样本中,埃博拉和马尔堡抗体的流行率最高。裂谷热病毒抗体在洛德瓦尔样本中也最高,其次是马林迪/基利菲和莱萨米斯。刚果出血热病毒抗体很少见,在所检测的1899份血清中未检测到针对拉沙病毒的抗体。

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