Nakounné E, Selekon B, Morvan J
Laboratoire des fièvres hémorragiques virales, Centre OMS de référence pour les maladies émergentes, Institut Pasteur, BP 923, Bangui, République centrafricaine.
Bull Soc Pathol Exot. 2000 Jan;93(5):340-7.
An investigation was conducted between 1994 and 1997 in forested areas of the Central African Republic (CAR) to determine the seroprevalence of IgG antibodies against several haemorrhagic fever viruses present in the region. Sera were obtained from 1762 individuals in two groups (Pygmy and Bantu locuted populations) living in 4 forested areas in the south of the country. Sera were tested for IgG antibodies against Ebola, Marburg, Rift Valley fever (RVF), Yellow fever (YF) and Hantaviruses by enzyme immunoassay (EIA), and against Lassa virus by immunofluorescent assay. The prevalence of IgG antibodies was 5.9% for Ebola, 2% for Marburg, 6.9% pour RVF, 6.5% for YF, 2% for Hantaan. No antibodies were detected against Lassa, Seoul, Puumala and Thottapalayam viruses. No IgM antibodies were detected against RVF and YF viruses. The distribution of antibodies appears to be related to tropical rain forest areas. This study indicates that several haemorrhagic fever viruses are endemic in forested areas of the CAR and could emerge due to environmental modification.
1994年至1997年期间，在中非共和国（CAR）的森林地区开展了一项调查，以确定该地区存在的几种出血热病毒的IgG抗体血清阳性率。血清取自该国南部4个森林地区的两组人群（俾格米人和班图语人群）中的1762人。通过酶免疫测定（EIA）检测血清中针对埃博拉病毒、马尔堡病毒、裂谷热（RVF）、黄热病（YF）和汉坦病毒的IgG抗体，并通过免疫荧光测定检测针对拉沙病毒的抗体。埃博拉病毒IgG抗体的阳性率为5.9%，马尔堡病毒为2%，裂谷热为6.9%，黄热病为6.5%，汉坦病毒为2%。未检测到针对拉沙病毒、首尔病毒、普马拉病毒和托塔帕拉亚姆病毒的抗体。未检测到针对裂谷热病毒和黄热病病毒的IgM抗体。抗体分布似乎与热带雨林地区有关。这项研究表明，几种出血热病毒在中非共和国的森林地区呈地方性流行，并且可能因环境变化而出现。
