Sage M R, Wilcox J
AJNR Am J Neuroradiol. 1983 Nov-Dec;4(6):1181-3.
Iopamidol, a nonionic, water-soluble contrast medium, has been recently recommended for myelography. As with other such media, the extent of parenchymal penetration is of interest in relation to the genesis of clinical complications. In this study the degree and depth of brain penetration of intrathecal iopamidol, using an iodine concentration of 280 mg l/ml, were compared at 15 and 60 min in adult greyhound dogs using coronal computed tomographic scanning of the brain after removal. A significant but patchy penetration corresponding to the cortical sulci was demonstrated at 15 min, while by 60 min there had been a further increase in the distribution and concentration of the contrast medium. Comparing the present study with a previous series using metrizamide and methylglucamine iothalamate at a similar iodine concentration (280 mg l/ml), no significant difference in the depth or degree of penetration at 60 min was found between the three contrast media, indicating a similar rate of diffusion across the cerebrospinal fluid/brain interface. Therefore, any difference in neurotoxicity is not explained by a reduced concentration of contrast medium due to variation in the rate of diffusion across this interface.
碘帕醇是一种非离子型水溶性造影剂，最近被推荐用于脊髓造影。与其他此类造影剂一样，实质渗透程度与临床并发症的发生有关。在本研究中，使用280mgI/ml的碘浓度，在成年灵缇犬鞘内注射碘帕醇后15分钟和60分钟，通过对取出的大脑进行冠状位计算机断层扫描，比较了碘帕醇在大脑中的渗透程度和深度。在15分钟时，发现与脑沟相对应的显著但不均匀的渗透，而到60分钟时，造影剂的分布和浓度进一步增加。将本研究与先前使用相同碘浓度（280mgI/ml）的甲泛葡胺和碘他拉葡胺的系列研究进行比较，发现三种造影剂在60分钟时的渗透深度或程度没有显著差异，这表明在脑脊液/脑界面的扩散速率相似。因此，任何神经毒性差异不能用由于在该界面扩散速率变化导致的造影剂浓度降低来解释。
