经颈动脉注射碘帕醇和碘他拉葡胺对血脑屏障破坏作用的比较。
Comparison of blood-brain barrier disruption by intracarotid iopamidol and methylglucamine iothalamate.
作者信息
Sage M R, Wilcox J, Evill C A, Benness G T
出版信息
AJNR Am J Neuroradiol. 1983 Jul-Aug;4(4):893-5.
Using a canine model, the effect of intracarotid injections of the ionic contrast medium methylglucamine iothalamate was compared with that of the nonionic contrast medium iopamidol of similar iodine concentration (280 mg 1/ml). The degree and distribution of blood-brain barrier disruption was assessed using Evans blue stain as a visual marker and by contrast enhancement measured by a computed tomographic (CT) scanner. In all studies with methylglucamine iothalamate, Evans blue staining was demonstrated, and CT enhancement demonstrated a significant mean difference (p less than 0.01) between the control and injected hemispheres. The absence of blood-brain barrier disruption with iopamidol is probably related to its lower osmolality (570 mosmol/kg) compared with methylglucamine iothalamate (1,424 mosmol/kg) and the absence of any cation.
利用犬类模型，比较了颈动脉内注射离子型造影剂碘他拉葡甲胺与碘浓度相似（280mgI/ml）的非离子型造影剂碘帕醇的效果。使用伊文思蓝染色作为视觉标记，并通过计算机断层扫描（CT）扫描仪测量的对比增强来评估血脑屏障破坏的程度和分布。在所有使用碘他拉葡甲胺的研究中，均显示出伊文思蓝染色，并且CT增强显示对照半球和注射半球之间存在显著的平均差异（p<0.01）。碘帕醇不存在血脑屏障破坏可能与其较低的渗透压（570 mosmol/kg）有关，相比之下碘他拉葡甲胺的渗透压为1424 mosmol/kg，且碘帕醇不存在任何阳离子。
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