（2'-5'）寡聚腺苷酸在不同血清中的稳定性
Stability of (2'-5')oligoriboadenylates in various sera.
作者信息
Vilcek S, Vrtiak O J, Smrt J, Jurovcík M
出版信息
FEBS Lett. 1984 Jan 30;166(2):311-3. doi: 10.1016/0014-5793(84)80102-7.
PMID:6420193
Abstract
Avian and mammalian sera were found to contain an enzyme activity degrading 2-5A oligonucleotides. The most extensive degradation of the A2' p5' A was observed in chicken serum. Degradation of this compound is not affected by the presence of cAMP, dsRNA, Mg2+, but is significantly inhibited by EDTA. The enzyme activity described is not inactivated by heating to 56 degrees C for 30 min. The 5-mU3' p5' A has also been degraded in chicken serum.
摘要
发现鸟类和哺乳动物血清中含有一种降解2-5A寡核苷酸的酶活性。在鸡血清中观察到A2' p5' A的降解最为广泛。该化合物的降解不受环磷酸腺苷（cAMP）、双链RNA（dsRNA）、镁离子（Mg2+）的影响，但会受到乙二胺四乙酸（EDTA）的显著抑制。所述酶活性在56摄氏度加热30分钟后不会失活。5-mU3' p5' A在鸡血清中也已被降解。
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