Rothwell J C, Obeso J A, Marsden C D
J Neurol Neurosurg Psychiatry. 1984 Jan;47(1):33-42. doi: 10.1136/jnnp.47.1.33.
Four patients with cortical myoclonus were studied. All had reflex muscle jerking and grossly enlarged somatosensory evoked responses (SEPs) following electrical stimulation of the digital nerves. In addition, three of the patients had spontaneous or action-induced myoclonus. Back-averaging the EEG from these spontaneous muscle jerks showed a large positive wave over the contralateral somatomotor cortex which preceded the jerk by about 20 ms. Administration of lisuride (0.1 mg iv) reduced the severity of the reflex and spontaneous myoclonus, but had no effect on, or increased the size of the SEP. Two of the patients also received 1 mg clonazepam iv. As with lisuride, the severity of myoclonic jerking was reduced although the size of the SEP was increased. It is concluded that the usual association between giant SEPs and reflex muscle jerking can be abolished by acute administration of lisuride and clonazepam in patients with cortical myoclonus.
对4例皮质肌阵挛患者进行了研究。所有患者在数字神经电刺激后均出现反射性肌肉抽搐和体感诱发电位（SEP）明显增大。此外，其中3例患者有自发性或动作诱发性肌阵挛。对这些自发性肌肉抽搐进行脑电图反向平均显示，对侧躯体运动皮层出现一个大的正波，该正波在抽搐前约20毫秒出现。静脉注射利苏立得（0.1毫克）可减轻反射性和自发性肌阵挛的严重程度，但对SEP无影响或使其增大。其中2例患者还静脉注射了1毫克氯硝西泮。与利苏立得一样，肌阵挛抽搐的严重程度降低，尽管SEP增大。结论是，在皮质肌阵挛患者中，急性给予利苏立得和氯硝西泮可消除巨大SEP与反射性肌肉抽搐之间的通常关联。
