Kuribara H, Tadokoro S
Psychopharmacology (Berl). 1984;82(1-2):36-40. doi: 10.1007/BF00426377.
Acquisition of conditioned lever-press avoidance behavior on a continuous avoidance schedule (response-shock interval = 30 s and shock-shock interval = 5 s) and on a discrete avoidance schedule (intertrial interval = 25 s and duration of the warning presentation = 5 s with an escape contingency) in dd mice was investigated. When the behavioral baseline had stabilized, the effects of diazepam on avoidance behaviors were examined. About 60% and 80% of the mice achieved criterion levels of avoidance behavior under continuous avoidance (shock rate being less than 0.5/min) and discrete avoidance (avoidance rate being higher than 75%), respectively. Diazepam (0.5--4 mg/kg SC) dose-dependently impaired avoidance behavior of mice which had a low baseline shock rate and a high baseline avoidance rate under continuous and discrete avoidances, respectively. The changes in avoidance behavior in mice after diazepam were almost identical with those previously found in rats.
研究了dd小鼠在连续回避程序（反应-电击间隔=30秒，电击-电击间隔=5秒）和离散回避程序（试验间隔=25秒，警告呈现持续时间=5秒且有逃避应急情况）下获得条件性杠杆按压回避行为的情况。当行为基线稳定后，检测了地西泮对回避行为的影响。分别约60%和80%的小鼠在连续回避（电击率小于0.5次/分钟）和离散回避（回避率高于75%）条件下达到了回避行为的标准水平。地西泮（0.5--4毫克/千克，皮下注射）分别剂量依赖性地损害了在连续和离散回避条件下基线电击率低和基线回避率高的小鼠的回避行为。地西泮处理后小鼠回避行为的变化与先前在大鼠中发现的变化几乎相同。
