Habibi B, Allain J P, Couroucé A M
Rev Fr Transfus Immunohematol. 1983 Nov;26(5):447-65. doi: 10.1016/s0338-4535(83)80116-0.
This report was presented at the June 1983 meeting of the Blood Transfusion National Consultative Commission at the French Ministry of Health. Clinical and epidemiological data on AIDS as well as problems raised by the lack of specific tests for screening of blood donors were briefly summarized. Out of 49 AIDS patients recorded in France up to April 1983, only one had a history of previous blood transfusion given in Haiti, 4 years before the clinical onset of the disease. Blood donors, all Haitians, had no sign and symptom of AIDS. Retrospective review of 2 300 hemophiliacs followed up in France until April 1983 disclosed no AIDS. However, in 6 patients, the following features, more or less associated, were found to be present: thrombocytopenia, neutropenia, micropolyadenopathy, splenomegaly, hypergammaglobulinemia and low OKT4/OKT8 ratio. No clear correlation could be found between these abnormalities and the origin, commercial or national, of the coagulation factor concentrates used for the treatment. Three main recommendations were proposed: -- information of blood donors and experimental evaluation of some non specific screening tests, in the at risk donor population. -- more cautious use of coagulation factor concentrates -- reduction of importations aiming at complete national self sufficiency concerning factor VIII concentrates.
本报告于1983年6月在法国卫生部输血全国咨询委员会会议上提出。简要总结了艾滋病的临床和流行病学数据以及缺乏献血者筛查特异性检测所引发的问题。截至1983年4月，法国记录的49例艾滋病患者中，只有1例在疾病临床发作前4年有过在海地接受输血的病史。献血者均为海地人，无艾滋病的体征和症状。对法国2300例血友病患者进行回顾性调查，截至1983年4月，未发现艾滋病病例。然而，在6例患者中，发现存在以下或多或少相关的特征：血小板减少、中性粒细胞减少、微多腺病、脾肿大、高球蛋白血症和低OKT4/OKT8比值。这些异常与用于治疗的凝血因子浓缩物的来源（商业或国内）之间未发现明显相关性。提出了三项主要建议：——告知献血者相关信息，并对高危献血人群中的一些非特异性筛查检测进行实验评估。——更谨慎地使用凝血因子浓缩物。——减少进口，以实现关于VIII因子浓缩物的完全国家自给自足。
