区域淋巴结细胞及抗体依赖性细胞毒性提取物的抑制作用。

Suppressive effects of regional lymph node cells and extracts of antibody-dependent cellular cytotoxicity.

作者信息

Catalona W J, Feldman A T, Ratliff T L, McCool R E

出版信息

J Urol. 1978 Mar;119(3):396-402. doi: 10.1016/s0022-5347(17)57501-1.

PMID:642097

Abstract

Lymphocytes from regional lymph nodes that drain tumors and extracts of such lymphocytes suppress antibody-dependent cell-mediated target cell lysis by effector cells from cancer patients and controls. In contrast, lymph node cells from control patients are not suppressive. Control extracts from normal lymphocytes and 2 immunologically inert tissues, muscle and kidney, exhibit some suppressive activity but significantly less than extracts from lymph nodes that drain tumors.

摘要

引流肿瘤的局部淋巴结中的淋巴细胞以及此类淋巴细胞的提取物，会抑制癌症患者和对照者的效应细胞介导的抗体依赖性细胞介导的靶细胞裂解。相比之下，对照患者的淋巴结细胞没有抑制作用。来自正常淋巴细胞以及2种免疫惰性组织（肌肉和肾脏）的对照提取物表现出一定的抑制活性，但明显低于引流肿瘤的淋巴结提取物。