Török B, Trombitás K, Röth E
Acta Morphol Hung. 1983;31(4):315-26.
Ultrastructural changes following ischaemic myocardial injury have been investigated in dogs. After 15 to 120 min global normothermic ischaemia the hearts were reperfused in a special heart-lung model for 60 min and then subjected to electron microscopic examination. The degree of morphological alterations and the duration of ischaemia were approximately interrelated. The ischaemic hearts showed characteristic changes such as mitochondrial, sarcolemmal and myofibrillar defects (swelling, disruption of cristae, loss of matrical density and contractile bands, myofibrillar rupture and lysis, blurred Z-lines). The hypercontractions are no artifacts but consequences of irreversible cellular injury and the observed stiffness during reperfusion is a good marker of the myocardial damage suffered.
已经在犬类中研究了缺血性心肌损伤后的超微结构变化。在进行15至120分钟的全身常温缺血后，心脏在特殊的心肺模型中再灌注60分钟，然后进行电子显微镜检查。形态学改变的程度与缺血持续时间大致相关。缺血心脏表现出特征性变化，如线粒体、肌膜和肌原纤维缺陷（肿胀、嵴断裂、基质密度丧失和收缩带、肌原纤维破裂和溶解、Z线模糊）。过度收缩不是人为现象，而是不可逆细胞损伤的后果，再灌注期间观察到的僵硬是心肌损伤的良好标志。
