Blume K G, Beutler E, Chillar R K, Fahey J L, Sharkoff D, Zia P K
JAMA. 1978 May 19;239(20):2149-51.
Adult patients with chronic iron overload were given oral ascorbic acid and continuous intravenous infusions of deferoxamine mesylate. The dosage of deferoxamine mesylate was altered every 48 hours from 1 g/sq m/24 hr to 2 or 4 g/sq m/24 hr. The average iron mobilization was 55.6 mg per day at the 1 g/sq m/24 hr dosage level, 78.6 mg every 24 hours at the 2 g/sq m/24 hr dosage level, and 90.1 mg every 24 hours at the 4 g/sq m/24 hr dosage level. Iron mobilization was undiminished when successive 14-day courses of deferoxamine separated by six-week intervals were administered.
患有慢性铁过载的成年患者口服了抗坏血酸，并持续静脉输注甲磺酸去铁胺。甲磺酸去铁胺的剂量每48小时从1 g/平方米/24小时调整为2或4 g/平方米/24小时。在1 g/平方米/24小时的剂量水平下，平均每日铁动员量为55.6毫克；在2 g/平方米/24小时的剂量水平下，每24小时为78.6毫克；在4 g/平方米/24小时的剂量水平下，每24小时为90.1毫克。当以六周为间隔连续给予14天的去铁胺疗程时，铁动员并未减少。
