Conte D, Brunelli L, Ferrario L, Mandelli C, Quatrini M, Velio P, Bianchi P A
Acta Haematol. 1984;72(2):117-20. doi: 10.1159/000206370.
The effect on urinary iron excretion (UIE) of vitamin C administered orally 2 h after the start of an 8-hour desferrioxamine (DF) i.v. infusion was studied in 12 patients with untreated idiopathic hemochromatosis (IH). Mean +/- SEM basal UIE of 324.6 +/- 84.6 micrograms/24 h increased after a 1-gram i.v. DF infusion to 8,778.5 +/- 1,191.4 micrograms/24 h; when vitamin C 1 or 2 g were added to DF i.v. infusion, there were further increases to 11,241.5 +/- 1,486.1 (p less than 0.01) and 13,531.2 +/- 1,697.2 micrograms/24 h (p less than 0.05 versus the last value), respectively. Basal UIE did not significantly increase after oral vitamin C administration alone. No side effects were observed.
在12例未经治疗的特发性血色素沉着症（IH）患者中，研究了在8小时静脉注射去铁胺（DF）开始2小时后口服维生素C对尿铁排泄（UIE）的影响。12例患者静脉注射1克DF后，平均±标准误的基础UIE从324.6±84.6微克/24小时增加到8,778.5±1,191.4微克/24小时；当在静脉注射DF时添加1克或2克维生素C时，UIE进一步分别增加到11,241.5±1,486.1微克/24小时（p<0.01）和13,531.2±1,697.2微克/24小时（与最后一个值相比p<0.05）。单独口服维生素C后基础UIE没有显著增加。未观察到副作用。
