Falkay G, Kovács L
Experientia. 1984 Feb 15;40(2):190-1. doi: 10.1007/BF01963593.
This comparative study on the effect of calcium dobesilate and indomethacin on prostaglandin biosynthesis was performed on microsomal fractions of pregnant human myometrium. Both drugs inhibited prostaglandin synthesis, indomethacin being more potent. Calcium dobesilate inhibited, in a dose-dependent manner, the synthesis of 6-oxo-PGF1 alpha, PGF2 alpha, PGE2 and TXB2. Its inhibitory action is comparable to that of etamsylate.
这项关于羟苯磺酸钙和吲哚美辛对前列腺素生物合成影响的比较研究是在人妊娠子宫肌层微粒体部分进行的。两种药物均抑制前列腺素合成，吲哚美辛的作用更强。羟苯磺酸钙以剂量依赖方式抑制6-氧代-前列环素F1α、前列腺素F2α、前列腺素E2和血栓素B2的合成。其抑制作用与酚磺乙胺相当。
