Piller N B
Faculty of Health, Science and Education, South Australian College of Advanced Education, Bedford Park.
Arzneimittelforschung. 1990 Jun;40(6):698-700.
Calcium dobesilate (Doxium) has been shown to significantly reduce the attachment of activated and quiescent macrophages to subcutaneously implanted coverslips in guinea pigs. Since the implanted coverslips represent an inflammatory stimulus and macrophages have a dominant role in inflammation it suggests that calcium dobesilate may have a pronounced anti-inflammatory action. It is speculated that calcium dobesilate may do this by reducing the number of circulating monocytes, by blocking the action of macrophage activating factors or more likely by stimulating a more rapid production of host macrophage deactivating factors such as Transforming Growth Factor (TGF) beta 1 and 2.
羟苯磺酸钙（多贝斯）已被证明能显著减少豚鼠皮下植入盖玻片上活化和静止巨噬细胞的附着。由于植入的盖玻片代表一种炎症刺激，且巨噬细胞在炎症中起主导作用，这表明羟苯磺酸钙可能具有显著的抗炎作用。据推测，羟苯磺酸钙可能通过减少循环单核细胞数量、阻断巨噬细胞激活因子的作用，或者更有可能是通过刺激宿主巨噬细胞失活因子（如转化生长因子（TGF）β1和β2）更快产生来实现这一点。
