Hayashi S, Park M K
Gen Pharmacol. 1984;15(1):19-24. doi: 10.1016/0306-3623(84)90074-0.
In dog mesenteric arteries, nialamide (10(-5) M), a monoamine oxidase inhibitor, potentiated contractile response to tyramine but not to noradrenaline or transmural electrical stimulation (TES). Bretylium, desipramine or prior reserpinization inhibited the potentiating action of nialamide on the tyramine-induced contraction. Contractions induced by octopamine were not reduced by prior reserpinization. In the coronary artery, relaxing responses to tyramine were potentiated but those to noradrenaline and TES were not potentiated by nialamide. In the cerebral artery, nialamide failed to potentiate tyramine-induced contraction. The functional role of intraneuronal monoamine oxidase in sympathomimetic effects is discussed.
在犬肠系膜动脉中，单胺氧化酶抑制剂尼亚酰胺（10⁻⁵ M）增强了对酪胺的收缩反应，但对去甲肾上腺素或跨壁电刺激（TES）无此作用。溴苄铵、地昔帕明或预先使用利血平可抑制尼亚酰胺对酪胺诱导收缩的增强作用。预先使用利血平不会降低章鱼胺诱导的收缩。在冠状动脉中，尼亚酰胺增强了对酪胺的舒张反应，但对去甲肾上腺素和TES的舒张反应无增强作用。在脑动脉中，尼亚酰胺未能增强酪胺诱导的收缩。本文讨论了神经元内单胺氧化酶在拟交感神经效应中的功能作用。
