Kikuyama S, Niki K, Mayumi M, Shibayama R, Nishikawa M, Shintake N
Gen Comp Endocrinol. 1983 Dec;52(3):395-9. doi: 10.1016/0016-6480(83)90178-8.
The effect of adrenal corticoids on the shrinkage of tail segments from Bufo bufo japonicus tadpoles was studied in vitro. Deoxycorticosterone acetate (DCA) was effective in accelerating the shrinkage of tail segments if thyroxine (T4) or triiodothyronine (T3) was present in the medium. The shrinkage caused by DCA was dose dependent. In the absence of thyroid hormone, DCA did not induce tail resorption. Shrinkage of tail segments induced by DCA and T4 was blocked by prolactin. Among the steroid hormones testes in vitro, aldosterone and corticosterone exhibited a potent activity in accelerating shrinkage of tail segments in the presence of T4. The nature of the corticoid action is discussed.
在体外研究了肾上腺皮质激素对日本蟾蜍蝌蚪尾部节段萎缩的影响。如果培养基中存在甲状腺素（T4）或三碘甲状腺原氨酸（T3），醋酸脱氧皮质酮（DCA）可有效加速尾部节段的萎缩。DCA引起的萎缩呈剂量依赖性。在没有甲状腺激素的情况下，DCA不会诱导尾部吸收。催乳素可阻断DCA和T4诱导的尾部节段萎缩。在体外测试的类固醇激素中，醛固酮和皮质酮在存在T4的情况下，在加速尾部节段萎缩方面表现出强大的活性。讨论了皮质激素作用的性质。
