Caceres E, Zaharia M, Valdivia S, Misad O, de la Flor J, Tejada F, Zubrod G
Int J Radiat Oncol Biol Phys. 1984 Jan;10(1):35-9. doi: 10.1016/0360-3016(84)90409-7.
Sixteen patients with osteogenic sarcoma of limbs were treated with high dose methotrexate followed by leucovorin rescue, adriamycin and radiotherapy to the primary tumor. A post-treatment surgical biopsy was performed in 15 of the 16 patients. In 12 of 15 patients (80%), the follow-up biopsy was negative for active tumor. Complications of treatment were myelosuppression (16 cases), moist desquamation (13 cases), soft tissue necrosis (2 cases) local infection (2 cases), fibrosis (9 cases) and bone fracture (4 cases). The mean survival time in this group of patients was 712 days.
16例肢体骨肉瘤患者接受了大剂量甲氨蝶呤治疗，随后进行亚叶酸钙解救、阿霉素治疗以及对原发肿瘤进行放疗。16例患者中有15例在治疗后进行了手术活检。在15例患者中的12例（80%），随访活检显示无活性肿瘤。治疗并发症包括骨髓抑制（16例）、湿性脱皮（13例）、软组织坏死（2例）、局部感染（2例）、纤维化（9例）和骨折（4例）。该组患者的平均生存时间为712天。
