Garrett B J, Cheeke P R
J Anim Sci. 1984 Jan;58(1):138-44. doi: 10.2527/jas1984.581138x.
Supplementation of the diets of rats with branched chain amino acids (BCAA: leucine, isoleucine, valine) did not alter their susceptibility to chronic poisoning by tansy ragwort (Senecio jacobaea), which contains hepatotoxic pyrrolizidine alkaloids (PA). Phenobarbital in the diet, which alters liver microsomal enzyme activity, also did not alter susceptibility to PA poisoning. A combination of butylated hydroxyanisole (BHA), cysteine and BCAA did increase (P less than .05) survival time of rats fed tansy ragwort. Dietary BHA and cysteine increased the survival time of rats injected with the PA monocrotaline, with evidence that addition of vitamin B12 and folic acid improved the effectiveness of this treatment. In a chronic feeding trial with tansy ragwort, a combination of BHA and cysteine increased (P less than .05) the survival times of rats, showing protective activity against PA poisoning. A mixture of B-complex vitamins, or vitamin B12-folic acid, was not effective in improving the response.
用支链氨基酸（BCAA：亮氨酸、异亮氨酸、缬氨酸）补充大鼠饮食，并未改变它们对含有肝毒性吡咯里西啶生物碱（PA）的千里光（Senecio jacobaea）慢性中毒的易感性。饮食中的苯巴比妥会改变肝微粒体酶活性，但也未改变对PA中毒的易感性。丁基羟基茴香醚（BHA）、半胱氨酸和BCAA的组合确实增加了（P小于0.05）喂食千里光的大鼠的存活时间。饮食中的BHA和半胱氨酸增加了注射PA野百合碱的大鼠的存活时间，有证据表明添加维生素B12和叶酸可提高这种治疗的效果。在一项用千里光进行的慢性喂养试验中，BHA和半胱氨酸的组合增加了（P小于0.05）大鼠的存活时间，显示出对PA中毒的保护活性。复合维生素B混合物或维生素B12 - 叶酸在改善反应方面无效。
