异丙肾上腺素诱导心肌坏死后心肌锌变化的时间曲线。
A temporal profile of myocardial zinc changes after isoproterenol induced cardiac necrosis.
作者信息
Mathew B M, Kumar S, Ahmad M S, Seth T D, Hasan M Z, Jamil S A
出版信息
Jpn Circ J. 1978 Mar;42(3):353-7. doi: 10.1253/jcj.42.353.
PMID:642204
Abstract
Changes in myocardial zinc level was followed up over a period of 5 days after producing myocardial necrosis in albino rats by subcutaneous injection of isoproterenol, 85 mg/kg body weight. Myocardial necrosis was confirmed by ECG (Lead II), histology and serum enzyme studies (SGOT, SGPT and LDH). A decrease in myocardial zinc level was observed on all the five days. The possible mechanism and the therapeutic implications of these changes are discussed.
摘要
通过皮下注射异丙肾上腺素（85毫克/千克体重）在白化大鼠中造成心肌坏死后，对心肌锌水平的变化进行了为期5天的跟踪研究。通过心电图（II导联）、组织学和血清酶研究（谷草转氨酶、谷丙转氨酶和乳酸脱氢酶）确认了心肌坏死。在所有五天中均观察到心肌锌水平下降。讨论了这些变化的可能机制及其治疗意义。
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