Goldenberg D L, Reed J I, Rice P A
J Rheumatol. 1984 Feb;11(1):3-8.
Intraarticular injections of viable N, gonorrhoeae, killed N. gonorrhoeae or gonococcal lipopolysaccharide (LPS) in rabbits' knees caused an acute, polymorphonuclear synovitis with abscess formation 24-72 h after the injection. At 5-7 days, a mononuclear infiltration with synovial lining cell hyperplasia developed, which in some rabbits persisted for one month. Gonococcal LPS, in amounts of 5 micrograms or greater, always caused a marked synovitis indistinguishable from that produced by viable N. gonorrhoeae. Gonococcal outer membrane protein used as a control in these experiments caused no or minimal synovitis in concentrations 50-fold higher than those used in the LPS inoculation experiments. These studies should provide a model to investigate the role of LPS in the arthritis associated with gonococcal infection.
向兔膝关节内注射活的淋病奈瑟菌、灭活的淋病奈瑟菌或淋球菌脂多糖（LPS），在注射后24 - 72小时会引发急性多形核滑膜炎并伴有脓肿形成。在5 - 7天时，出现单核细胞浸润并伴有滑膜衬里细胞增生，部分兔子的这种情况会持续一个月。5微克及以上剂量的淋球菌LPS总是会引发明显的滑膜炎，与活的淋病奈瑟菌所引发的滑膜炎无法区分。在这些实验中用作对照的淋球菌外膜蛋白，在浓度比LPS接种实验中所用浓度高50倍时，未引发或仅引发轻微的滑膜炎。这些研究应为探究LPS在淋球菌感染相关关节炎中的作用提供一个模型。
