Itoh K, Fukumori R, Suzuki Y
Life Sci. 1984 Feb 27;34(9):827-33. doi: 10.1016/0024-3205(84)90199-1.
The present studies were carried out to examine a possible role of hippocampal dopamine in the hyperactivity induced by methamphetamine. For this purpose, 6-hydroxydopamine (6-OHDA) lesion of the dorsal hippocampus (D-HPC) was made in desmethylimipramine pretreated rats in order to specifically destroy dopamine neurons. D-HPC lesions produced a large (96%) and selective depletion of content of dopamine in the D-HPC. This lesion did not change spontaneous locomotion and rearing behavior. The 6-OHDA lesioned rat produced a blockade of the increase in locomotor activity induced by 1.0 and 2.0 mg/kg of methamphetamine. In contrast, the 6-OHDA lesion of the D-HPC failed to influence the methamphetamine-induced rearing activity. These results indicate that dopamine neurons in the D-HPC may have some role in methamphetamine-induced locomotion, but not in methamphetamine-induced rearing.
开展本研究以检验海马多巴胺在甲基苯丙胺诱导的多动中可能发挥的作用。为此，在经去甲丙咪嗪预处理的大鼠中对背侧海马（D-HPC）进行6-羟基多巴胺（6-OHDA）损伤，以特异性破坏多巴胺能神经元。D-HPC损伤导致D-HPC中多巴胺含量大幅（96%）且选择性地耗竭。该损伤未改变自发运动和竖毛行为。6-OHDA损伤的大鼠对1.0和2.0mg/kg甲基苯丙胺诱导的运动活性增加产生了阻断作用。相比之下，D-HPC的6-OHDA损伤未能影响甲基苯丙胺诱导的竖毛活性。这些结果表明，D-HPC中的多巴胺能神经元可能在甲基苯丙胺诱导的运动中发挥一定作用，但在甲基苯丙胺诱导的竖毛行为中不起作用。
