Prakash S, Mehra N K, Bhargava S, Malaviya A N
Rheumatol Int. 1983;3(3):101-4. doi: 10.1007/BF00541187.
Thirty-six patients fulfilling the criteria for Reiter's disease were studied (29 men and 7 women; 4:1). The mean age of onset was 23.8 years; in 75% of patients the onset was in the second and third decades. Clinical manifestations included low back pain and stiffness (69%), non specific urethritis (53%), heel pain (44%), radiographic sacroiliitis (42%), conjunctivitis (39%), dysentery and diarrhoea (33%), mucosal ulcerations (17%) kidney disease (14%), anterior uveitis (19%), and keratoderma blennorrhagicum (8%). Peripheral arthritis was mono or oligoarthritis in 58% of patients, mainly affecting the large joints of lower extremities, and it was often asymmetric (mean degree of asymmetry = 0.37). HLA-B27 antigen was detected in 83% of 36 patients compared with 5.9% of 118 controls (relative risk 79, corrected Fisher's P = 7.719E-18).
对36例符合赖特综合征标准的患者进行了研究（29例男性和7例女性，比例为4:1）。平均发病年龄为23.8岁；75%的患者发病于第二和第三个十年。临床表现包括腰背痛和僵硬（69%）、非特异性尿道炎（53%）、足跟痛（44%）、影像学骶髂关节炎（42%）、结膜炎（39%）、痢疾和腹泻（33%）、黏膜溃疡（17%）、肾脏疾病（14%）、前葡萄膜炎（19%）和脓性角化病（8%）。58%的患者外周关节炎为单关节炎或寡关节炎，主要累及下肢大关节，且通常不对称（平均不对称程度=0.37）。36例患者中有83%检测到HLA - B27抗原，而118例对照中只有5.9%检测到（相对风险79，校正费舍尔P值=7.719E - 18）。
