Danesi M A
Trop Geogr Med. 1983 Dec;35(4):395-9.
One hundred and four unselected adolescent and adult epileptics treated in Lagos University Teaching Hospital were followed up for 3 years to determine their seizure prognosis. We found 37% completely free of seizures; marked improvement in 30%, moderate improvement in 11%, slight improvement in 10% and no improvement in seizure control in 13% of the patients. The study also indicated that prognosis of seizure control is more favourable: (a) in generalised than in partial epilepsy; (b) in patients with onset of seizures after the age of 10 years and in particular after the age of 30 years; (c) in patients with less frequent seizures; (d) in patients who started treatment within 2 years of onset of seizures; (e) in patients who had initially a normal EEG. The prognosis of seizure control was less favourable in patients who were treated with native herbs by traditional healers prior to hospital treatment probably because the majority of them started medical treatment later than 2 years after the onset of seizures. There was no relationship between seizure prognosis and the number of anti-epileptic drugs taken by the patients. Most of the patients (79%) claimed they took drugs regularly although there were no serum levels to confirm these claims. There was no relationship between seizure prognosis and drug compliance as claimed by the patients.
对在拉各斯大学教学医院接受治疗的104例未经挑选的青少年及成年癫痫患者进行了为期3年的随访，以确定其癫痫发作的预后情况。我们发现37%的患者完全无癫痫发作；30%有显著改善，11%有中度改善，10%有轻度改善，13%的患者癫痫控制无改善。该研究还表明癫痫控制的预后更有利的情况为：(a)全身性癫痫比部分性癫痫；(b)癫痫发作始于10岁以后尤其是30岁以后的患者；(c)癫痫发作频率较低的患者；(d)在癫痫发作开始2年内开始治疗的患者；(e)最初脑电图正常的患者。在医院治疗前由传统治疗师用草药治疗的患者中，癫痫控制的预后较差，可能是因为他们中的大多数在癫痫发作开始2年后才开始药物治疗。癫痫发作预后与患者服用抗癫痫药物的数量之间没有关系。大多数患者（79%）声称他们定期服药，尽管没有血清水平来证实这些说法。癫痫发作预后与患者声称的药物依从性之间没有关系。
