Kulakov G P
Z Urol Nephrol. 1983 Dec;76(12):789-94.
Commonly the pathogenesis of acute renal failure (ARF) in the first place takes into consideration acute circulatory and acute toxic nephropathies. But disturbances in humoral regulations are important as well. Compensatory-adaptional reactions of the kidney answering the tubular lesion are causing increasing serum levels of renin, serotonin and histamin accompanied by a consecutive decrease of the diaminoxidase-activity, the latter as the hormone inactivating histamin. The results obtained form trials due to the dynamic behaviour of serotonin, histamin and diaminoxidase in the serum and urine respectively of 17 healthy persons (control), of 17 women with an ARF after abortation and of 5 patients with ARF from complications during pregnancy are reported. Rational managment of ARF should purchase an improvement in renal perfusion, the correction of metabolic deviation--among others--an increase of the diaminoxidase-activity.
通常，急性肾衰竭（ARF）的发病机制首先会考虑急性循环性和急性中毒性肾病。但体液调节紊乱也很重要。肾脏对肾小管损伤的代偿适应性反应会导致血清肾素、血清素和组胺水平升高，同时二胺氧化酶活性持续降低，后者是使组胺失活的激素。报告了分别对17名健康人（对照组）、17名流产后发生ARF的女性以及5名妊娠并发症导致ARF的患者的血清和尿液中血清素、组胺和二胺氧化酶的动态行为进行试验所获得的结果。ARF的合理管理应改善肾脏灌注，纠正代谢偏差，其中包括提高二胺氧化酶活性。
