Magilligan D J, Oyama C, Klein S, Riddle J M, Smith D
Am J Cardiol. 1984 Mar 15;53(7):945-9. doi: 10.1016/0002-9149(84)90530-7.
Tissue from porcine aortic bioprosthetic valves (Hancock) and bovine pericardial valves (Ionescu-Shiley) were incubated with platelets tagged with chromium-51. There was a significantly decreased platelet-collagen adhesion reaction in both porcine and bovine glutaraldehyde-treated valves compared with reactions in fresh porcine aortic valve and fresh bovine pericardium (p less than 0.001). There was no significant difference in the platelet-collagen reaction between porcine aortic valve and bovine pericardium, whether treated with glutaraldehyde or in the fresh state (p greater than 0.05). The addition of aspirin did not significantly decrease the platelet-collagen reaction on glutaraldehyde-treated or fresh valves (p greater than 0.05). Rinsing fresh valves in plasma appeared to offer more protection against platelet adhesion than rinsing them in saline solution (p less than 0.01). It is concluded that there is no difference in platelet adherence to porcine aortic valve or bovine pericardium and that glutaraldehyde, and perhaps plasma, offers a protective effect against platelet adhesion.
将来自猪主动脉生物瓣膜（汉考克）和牛心包瓣膜（伊奥内斯库 - 希利）的组织与用铬 - 51标记的血小板一起孵育。与新鲜猪主动脉瓣膜和新鲜牛心包中的反应相比，经戊二醛处理的猪和牛瓣膜中的血小板 - 胶原黏附反应均显著降低（p小于0.001）。无论是经戊二醛处理还是处于新鲜状态，猪主动脉瓣膜和牛心包之间的血小板 - 胶原反应均无显著差异（p大于0.05）。添加阿司匹林并未显著降低戊二醛处理或新鲜瓣膜上的血小板 - 胶原反应（p大于0.05）。在血浆中冲洗新鲜瓣膜似乎比在盐溶液中冲洗能提供更多针对血小板黏附的保护作用（p小于0.01）。得出的结论是，血小板对猪主动脉瓣膜或牛心包的黏附没有差异，并且戊二醛，或许还有血浆，对血小板黏附具有保护作用。
