霍奇金淋巴瘤。放射治疗项目的结果。

Hodgkin's disease. Results from a program in radiation therapy.

作者信息

Micaily B, Brady L W

出版信息

Am J Clin Oncol. 1984 Apr;7(2):159-71.

Abstract

From January 1965 to December 1975, 122 patients diagnosed with Hodgkin's disease, Stage I-A, II-A, and III-A were treated at the Department of Radiation Therapy at Hahnemann Medical College and Hospital. Twenty-five patients with Stage I-A, 54 patients with Stage II-A, and 43 patients with Stage III-A were accepted for treatment. Retrospective analysis was made to define the impact of the cell type, clinical and pathologic stage, and tumor bulk on prognosis. Of the 25 patients with Stage I-A Hodgkin's disease, 13 were clinically staged and 12 pathologically staged. Nine patients received extended-field radiation therapy with the overall relapse-free survival of 100% at 5 and 9 years; 16 patients received mantle radiation only, with overall survival of 84% and relapse-free survival of 68% at 5 and 10 years. Of 54 patients with Stage II-A Hodgkin's disease (32 clinically staged and 22 pathologically staged), six patients received involved field radiation therapy with overall survival of 68 and 49% at 5 and 10 years, and relapse-free survival of 33 and 17% at 5 and 10 years. Nineteen patients received limited-field radiation therapy (mantle or inverted Y) with overall survival of 49% at 5 and 10 years, and relapse-free survival of 42 and 31% at 5 and 10 years, and 29 patients received extended-field radiation therapy (mantle and para-aortic or TNI) with overall survival of 88% at 5 and 10 years, and relapse-free survival of 82 and 73% at 5 and 10 years. The overall and relapse-free survival at 5 and 10 years in 22 patients pathologically staged II-A (treated by different techniques) are 95 and 75%. Forty-three patients with Stage III-A Hodgkin's disease (treated with different techniques) reveal an overall survival of 79 and 64% at 5 and 10 years, and relapse-free survival of 58 and 45% at 5 and 10 years. Complications consisted of six patients with overt symptoms of hypothyroidism, two patients with peripheral neuropathy, one patient with radiation myelitis, and two patients with symptoms of leukoencephalopathy. Two patients developed second malignancies.

摘要

1965年1月至1975年12月，哈内曼医学院及医院放射治疗科对122例诊断为I - A期、II - A期和III - A期霍奇金病的患者进行了治疗。其中25例I - A期、54例II - A期和43例III - A期患者接受了治疗。通过回顾性分析来确定细胞类型、临床和病理分期以及肿瘤体积对预后的影响。在25例I - A期霍奇金病患者中，13例为临床分期，12例为病理分期。9例患者接受扩大野放射治疗，5年和9年的总无复发生存率为100%；16例患者仅接受斗篷野放射治疗，5年和10年的总生存率为84%，无复发生存率为68%。在54例II - A期霍奇金病患者（32例临床分期，22例病理分期）中，6例患者接受累及野放射治疗，5年和10年的总生存率分别为68%和49%，无复发生存率分别为33%和17%。19例患者接受局限野放射治疗（斗篷野或倒Y野），5年和10年的总生存率为49%，无复发生存率分别为42%和31%，29例患者接受扩大野放射治疗（斗篷野加腹主动脉旁或TNI），5年和10年的总生存率为88%，无复发生存率分别为82%和73%。22例病理分期为II - A期（采用不同技术治疗）患者5年和10年的总生存率及无复发生存率分别为95%和75%。43例III - A期霍奇金病患者（采用不同技术治疗）5年和10年的总生存率分别为79%和64%，无复发生存率分别为58%和45%。并发症包括6例有明显甲状腺功能减退症状的患者、2例周围神经病变患者、1例放射性脊髓炎患者和2例脑白质病症状患者。2例患者发生了第二原发性恶性肿瘤。