Cabezudo I, Thompson R L, Selden R F, Guenthner S H, Wenzel R P
Antimicrob Agents Chemother. 1984 Jan;25(1):4-6. doi: 10.1128/AAC.25.1.4.
Cefsulodin sodium is a narrow-spectrum cephalosporin with marked in vitro activity against clinical isolates of Pseudomonas aeruginosa. We have studied the antibiotic in a clinical trial in 10 patients admitted to the Pediatric Ward of the University of Virginia Medical Center with cystic fibrosis and recurrent acute lower respiratory tract infections with P. aeruginosa isolated from their sputa. The patients received 500 to 1,500 mg of cefsulodin every 6 hours by intravenous infusion for 10 to 22 days. Mean peak drug levels in plasma after 500, 1,000, and 1,500 mg were 46, 71, and 90 micrograms/ml, respectively, and the mean minimal inhibitory concentration of all organisms was 7.5 micrograms/ml. Detectable levels of cefsulodin in sputa were found in approximately half of the random samples and ranged from 2 to 5 micrograms/ml. The clinical response was satisfactory in nine (90%) of the patients. One patient gained weight and had improved pulmonary function tests but showed no reduction in sputum production and no improvement in arterial blood gas values. In pulmonary function tests, four of five patients tested showed an average 43% increase in forced vital capacity after initiation of therapy and five of five had an average 51% increase in forced expired volume in 1 s. No adverse effects were observed.
磺苄西林钠是一种窄谱头孢菌素，对铜绿假单胞菌临床分离株具有显著的体外活性。我们在弗吉尼亚大学医学中心儿科病房对10例患有囊性纤维化且反复发生急性下呼吸道感染、痰液中分离出铜绿假单胞菌的患者进行了一项关于该抗生素的临床试验。患者每6小时静脉输注500至1500毫克磺苄西林钠，持续10至22天。500毫克、1000毫克和1500毫克剂量后血浆中的平均药物峰值水平分别为46微克/毫升、71微克/毫升和90微克/毫升，所有菌株的平均最低抑菌浓度为7.5微克/毫升。在大约一半的随机痰液样本中检测到了可检测水平的磺苄西林钠，范围为2至5微克/毫升。9名（90%）患者的临床反应令人满意。一名患者体重增加，肺功能测试有所改善，但痰液分泌未减少，动脉血气值也未改善。在肺功能测试中，接受测试的5名患者中有4名在开始治疗后用力肺活量平均增加了43%，5名患者中有5名在1秒用力呼气量平均增加了51%。未观察到不良反应。
